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Patil, R. A.
- Antihyperlipidemic and Antiperoxidative Effect of Dibola a Polyherbal Formulation in Alloxan Induced Diabetic Rats
Abstract Views :231 |
PDF Views:0
Authors
B. C. Koti
1,
R. A. Patil
2
Affiliations
1 Tatyasaheb Kore College of Pharmacy, Warananagar, IN
2 Tatyasaheb Kore College of Pharmacy, Warananagar. Tal-Panhala, Dist-Kolhapur. Pin-416113, IN
1 Tatyasaheb Kore College of Pharmacy, Warananagar, IN
2 Tatyasaheb Kore College of Pharmacy, Warananagar. Tal-Panhala, Dist-Kolhapur. Pin-416113, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 2 (2012), Pagination: 102-107Abstract
This study was undertaken to investigate the effect of Dibola, a polyherbal formulation composed of medicinal plants on blood glucose, plasma insulin, serum lipid profile and lipidperoxidation in alloxan induced diabetes rats. Dibola, was administered orally (242 mg/kg body weight) for 21 days. The effect of Dibola on blood glucose and plasma insulin in diabetic rats were studied and the levels of lipid peroxides [TBARS and Hydroperoxides] and serum lipids [cholesterol, triglyceride, LDL, HDL and VLDL] were also estimated in alloxan induced diabetic rats. The effects were compared with standard drug Gilbenclamide. Treatment with Dibola and Gilbenclamide resulted in a significant reduction of blood glucose and increase in plasma insulin. Dibola also resulted in a significant decrease in serum cholesterol, increase HDL and reduction in tissue lipid peroxide formation. The effect produced by Dibola was comparable with that of Gilbenclamide.The decreased lipid peroxides, serum cholesterol, increase HDL levels clearly showed the antihyperlipidemic and antiperoxidative effect of Dibola apart from its antidiabetic effect.
Keywords
Dibola, Alloxan, Antihyperlipidemic, Antiperoxidative.
References
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- Saravanan R, Pari L. Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC Compl Alt Med. 2005;5:1-8.
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- Snehal SP., Rajendra SS., Ramesh KG. Antihyperglycemic antihyperlipidemic and antioxidant effects of Dihar polyherbal ayurvedic formulation in STZ induced diabetic rats. Ind J Exp Biol. 2009;47:564-70.
- Devasagayam TP., Boloor KK. Methods for estimating lipid peroxidation. An analysis of merits and demerits. Ind J of Biochem and Biophysics. 2003;40:300-08.
- Eva Sodergren., Nourooz-Zadeh J., Berglund L., Vessby B.. Reevaluation of the ferrous oxidation in xylenol orange assay for the measurement of plasma lipid hydroperoxides. J. Biochem. Biophys Methods. 1998;37:137–46.
- Szkudelski T. The mechanism of alloxan and streptozotocin action in β-cells of the pancreas. Physiol Res. 2001;50:536-46.
- Friedwald WT., Robert IL, Estimation of low density lipoprotein cholesterol in plasma, without use of the preparation of ultracentrifugation. Clin Chem. 1972;18(6):499-502.
- Baynes JW: Reactive oxygen in the aetiology and complications of diabetes. In Drug, Diet and Disease. Mechanistic Approach to Diabetes Volume 2. Edited by: Ioannides C, Flatt PR. Hertfordshive: Ellis Horwood limited. 1995:230-31.
- Sanjay J., Gaurav B., Rakesh B., Praveen K., Avnish J., Vinod KD. Antidiabetic activity of Paspalum Scrobiculatum Linn. in alloxan induced diabetic rats. J Ethnopharmacol. 2010;127:325–28.
- Chatopadhyay RR. Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract: Part V. J Ethnopharmacol. 1999;67:373-76.
- Hydrometeors Classification Using Fuzzy Logic for Cloud Radars
Abstract Views :222 |
PDF Views:5
Authors
Swapnil R. Gupta
1,
Arvind Agarwal
2,
R. A. Patil
3,
Aurobindo Krishnan
4,
G. S. Isola
4,
S. J. Pillai
4
Affiliations
1 Civil Department, IIT Bombay, IN
2 Dept. of Radar Division-1, S.A.M.E.E.R., IIT Campus, Powai, Mumbai-400076, Maharashtra, IN
3 Government College of Engineering, Pune-411005, Maharashtra, IN
4 S.A.M.E.E.R., IIT Campus, Powai, Mumbai-400076, Maharashtra, IN
1 Civil Department, IIT Bombay, IN
2 Dept. of Radar Division-1, S.A.M.E.E.R., IIT Campus, Powai, Mumbai-400076, Maharashtra, IN
3 Government College of Engineering, Pune-411005, Maharashtra, IN
4 S.A.M.E.E.R., IIT Campus, Powai, Mumbai-400076, Maharashtra, IN
Source
Automation and Autonomous Systems, Vol 2, No 10 (2010), Pagination: 149-153Abstract
A new synthesis of information forming the foundation for rule-based systems to deduce dominant bulk hydrometeor types and amounts using polarimetric radar data is presented. The relations are expressed as boundaries and thresholds in a space of polarimetric radar variables. Thus, the foundation is laid out for identification of hydrometeor types (species), estimation of characteristics of hydrometeor species (concentrations, shapes, sizes, and orientations) and quantification of bulk hydrometeor contents (amounts). This study presents a methodology to readily adapt and tune fuzzy logic algorithms using polarimetric observations. Because the design of the weighting functions is based entirely on observations, this method may be applied in the tropics or mid-latitudes at X-, C-, S-, or Ka-band wavelengths.Keywords
Reflectivity Factor (Zh), Differential Reflectivity (Zdr), Specific Differential Phase (Kdp), Correlation Coefficient (ρhv), Linear Depolarization Ratio (L.D.R.).- Thermo-Acoustical Characteristics of Binary Mixture of Acetone and Aniline in Pyridine
Abstract Views :184 |
PDF Views:6
Authors
Affiliations
1 Department of Physics, Bhalerao Science College, Saoner, Nagpur-441107, IN
2 Department of Physics, Government Institute of Science, Nagpur-440001, IN
3 SSSKR Innani College, Karanja (lad), Washim-444105, IN
1 Department of Physics, Bhalerao Science College, Saoner, Nagpur-441107, IN
2 Department of Physics, Government Institute of Science, Nagpur-440001, IN
3 SSSKR Innani College, Karanja (lad), Washim-444105, IN
Source
Journal of Pure and Applied Ultrasonics, Vol 38, No 4 (2016), Pagination: 110-114Abstract
The two binary systems : acetone and pyridine and aniline and pyridine at different temperatures have been studied to determine the different ultrasonic parameters. The measured values of density, ultrasonic velocity and coefficient of viscosity shows increasing trend with the increase in concentration of acetone in the mixture of pyridine. The nature of the curves of compressibility, free length, free volume show decreasing trend with that of increase in the concentration of acetone or aniline in their respective mixture. The internal pressure of both the binary mixture is found to increase with the corresponding increase in concentration of the acetone or aniline in their binary mixture. The excess values of the above parameters such as, excess velocity υE, excess adiabatic compressibility υαE, excess free length LfE, excess free volume VfE and excess internal pressure πiE have also been evaluated and the results presented graphically. The data confirms the existence of interaction between the components of the binary mixtures.Keywords
Molecular Interaction, Free Volume, Ultrasonic Velocity, Internal Pressure, Excess Parameters.Full Text